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selective mc4r antagonists  (Santhera Pharmaceuticals)

 
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    Santhera Pharmaceuticals selective mc4r antagonists
    Selective Mc4r Antagonists, supplied by Santhera Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/selective+mc4r+antagonists/mc+4r+antagonist+program+bl+6020+979/pm20367196-25-19-2
    Average 90 stars, based on 1 article reviews
    selective mc4r antagonists - by Bioz Stars, 2026-10
    90/100 stars

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    <t>Melanocortin</t> <t>receptor-4</t> <t>(MC4R)</t> gene expression in HT-29, 8305C, and Caco-2 cell lines assessed by Real-Time PCR analysis; glyceraldehyde 3-phosphate dehydrogenase (GAPDH); the results are shown as fold changes relative to GAPDH expression.
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    selective mc4r antagonists  (Santhera Pharmaceuticals)
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    selective mc4r antagonist  (Dawley Inc)
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    Image Search Results


    Melanocortin receptor-4 (MC4R) gene expression in HT-29, 8305C, and Caco-2 cell lines assessed by Real-Time PCR analysis; glyceraldehyde 3-phosphate dehydrogenase (GAPDH); the results are shown as fold changes relative to GAPDH expression.

    Journal: Journal of Clinical Medicine

    Article Title: Melanocortin-4 Receptor Antagonism Inhibits Colorectal and Anaplastic Thyroid Cancer In Vitro and In Vivo

    doi: 10.3390/jcm14041165

    Figure Lengend Snippet: Melanocortin receptor-4 (MC4R) gene expression in HT-29, 8305C, and Caco-2 cell lines assessed by Real-Time PCR analysis; glyceraldehyde 3-phosphate dehydrogenase (GAPDH); the results are shown as fold changes relative to GAPDH expression.

    Article Snippet: The ML00253764 compound (Cat. No. 4854/10) (chemical name: 2-[2-[2-(5-Bromo-2-methoxyphenyl) ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride), a small-molecule (non-peptide) selective MC4R antagonist was obtained from Tocris Bioscience (Bristol, UK), and was solubilized in sterile water.

    Techniques: Gene Expression, Real-time Polymerase Chain Reaction, Expressing

    Immunofluorescence of 8305C cells stained with MC4R-antibody ( A ) and negative control ( B ), performed by omission of the primary antibody; immunofluorescence of HT-29 cells stained with MC4R-antibody ( C ) and negative control ( D ).

    Journal: Journal of Clinical Medicine

    Article Title: Melanocortin-4 Receptor Antagonism Inhibits Colorectal and Anaplastic Thyroid Cancer In Vitro and In Vivo

    doi: 10.3390/jcm14041165

    Figure Lengend Snippet: Immunofluorescence of 8305C cells stained with MC4R-antibody ( A ) and negative control ( B ), performed by omission of the primary antibody; immunofluorescence of HT-29 cells stained with MC4R-antibody ( C ) and negative control ( D ).

    Article Snippet: The ML00253764 compound (Cat. No. 4854/10) (chemical name: 2-[2-[2-(5-Bromo-2-methoxyphenyl) ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride), a small-molecule (non-peptide) selective MC4R antagonist was obtained from Tocris Bioscience (Bristol, UK), and was solubilized in sterile water.

    Techniques: Immunofluorescence, Staining, Negative Control

    Immunoblotting of MC4R protein from total cellular lysates of HT-29 and Caco-2 cell lines and endothelial cells (HUVEC). The western blot bands correspond to MC4R and β-tubulin.

    Journal: Journal of Clinical Medicine

    Article Title: Melanocortin-4 Receptor Antagonism Inhibits Colorectal and Anaplastic Thyroid Cancer In Vitro and In Vivo

    doi: 10.3390/jcm14041165

    Figure Lengend Snippet: Immunoblotting of MC4R protein from total cellular lysates of HT-29 and Caco-2 cell lines and endothelial cells (HUVEC). The western blot bands correspond to MC4R and β-tubulin.

    Article Snippet: The ML00253764 compound (Cat. No. 4854/10) (chemical name: 2-[2-[2-(5-Bromo-2-methoxyphenyl) ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride), a small-molecule (non-peptide) selective MC4R antagonist was obtained from Tocris Bioscience (Bristol, UK), and was solubilized in sterile water.

    Techniques: Western Blot

    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .

    Journal: bioRxiv

    Article Title: Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

    doi: 10.1101/2022.11.28.518266

    Figure Lengend Snippet: (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .

    Article Snippet: A dose-response curve was performed for a selective MC4R antagonist, M4603 (Sigma Aldrich, #SHU9119), which binds aMSH.

    Techniques: Imaging, Injection